Implanted tooth and dental pulp stem cells could produce mature bones

A new Japanese study has shown that stem cells derived from canine teeth and dental pulp can be used to produce bone regeneration between parents and offspring.

The researchers said that stem cells could be easily extracted from deciduous teeth, which are routinely lost in childhood and generally discarded.

“Stem cells from human exfoliated deciduous teeth were identified as a novel population of stem cells, capable of differentiating into various cell types, such as osteoblasts, odontoblasts, adipocytes and neural cells,” said study corresponding author Dr. Yoichi Yamada of the Center for Genetic and Regenerative Medicine at the Nagoya University School of Medicine.

Their study extracted deciduous teeth from canine puppies and grafted them onto parent canine mandibles as an allograft.

After four weeks, bone defects were prepared on both sides of the host mandible. The newly formed bone was evaluated at two, four and eight weeks.

When compared to controls, the study group demonstrated well-formed mature bone and neovascularization.

Their results were published in Cell Transplantation.

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