llumina, Inc. today announced it has expanded the world’s most comprehensive next-generation sequencing (NGS) portfolio with the launch of the HiSeq X Five System and HiSeq 3000/4000 Systems. Over the last five years, the HiSeq Sequencing System family has been established as the platform of choice for high-throughput, production-scale sequencing laboratories. The new systems bring to market technology innovations and cost reductions that enable high-throughput laboratories to significantly increase their productivity.
Illumina introduced also the NextSeq 550 System, the first NGS system enabled for array scanning. The system’s initial applications are for cytogenetics and prenatal genetic diagnosis (PGD). The company also unveiled a roadmap for further market expansion in the areas of reproductive health and oncology.
“Illumina technology has broken down barriers in genomics by increasing data throughput at an astounding rate, while at the same time dramatically reducing the price per data point,” said Jay Flatley, Illumina’s Chief Executive Officer. “These advancements enable us to deliver the industry’s simplest, most efficient sequencing experience to our research and clinical customers as they work to forever transform our understanding of genomics and medicine.”
HiSeq X Five System
Illumina delivered the world’s first $1,000 genome in 2014 with the HiSeq X Ten System, a set of 10 HiSeq X instruments, which enables a single laboratory to sequence approximately 18,000 high-quality, high-coverage human whole genomes per year. For laboratories wanting to take advantage of HiSeq X technology for human whole genome sequencing (WGS) at a smaller scale, Illumina now offers the HiSeq X Five System.
The HiSeq X Five, which consists of five individual HiSeq X instruments, allows production centers to adopt high-throughput WGS with a lower capital investment and at an attractive price per genome. At full utilization, the five instruments provide the throughput to sequence more than 9,000 genomes a year. The HiSeq X Five makes high-throughput human WGS more accessible, enabling production-scale sequencing to be performed in more laboratories.
HiSeq 3000/4000 Sequencing Systems
Building on the proven performance of the HiSeq 2500 System and leveraging patterned flow cell technology originally developed for the HiSeq X Ten System, the HiSeq 3000/4000 Systems provide unparalled speed and performance for the full range of high-throughput sequencing applications.
The innovative patterned flow cell technology enables the HiSeq 3000 (using a single flow cell) and the HiSeq 4000 (using dual flow cells) to deliver an exceptional level of throughput, at a lower price per data point than the HiSeq 2500. With the ability to process one or two flow cells simultaneously, the HiSeq 4000 can sequence up to 12 genomes, 100 whole transcriptome samples, or 180 exomes in 3.5 days or less. Using a single flow cell, the HiSeq 3000 can produce half the throughput at the same price per sample as the HiSeq 4000. These capabilities set a new standard for cost-effective, high-throughput production-scale sequencing across multiple applications.
The NextSeq 550 System combines microarray scanning with the proven and robust NextSeq 500 Sequencing System. By leveraging microarray scanning on the NextSeq 550, researchers have access to a powerful, complementary technology for further exploration or confirmation of copy number variants detected through sequencing. The initial arrays qualified for the system are for cytogenetics and PGD applications. Illumina’s BlueFuse software is integrated into the system, creating a streamlined workflow for data management and analysis. The NextSeq 550 will enable a broad range of applications in reproductive health, genetic health, and oncology-related research.
The HiSeq X Five, HiSeq 3000/4000, and NextSeq 550 Systems are now available for order.