Researchers at the University of California, San Diego School of Medicine, have discovered that expression of a newly identified human cytokine can protect mice from ulcerative colitis, or inflammation of the lining of the colon.
Interleukin 37 (IL-37) is a member of the IL-1 family and functions as an inhibitor of innate inflammation and immunity. While most molecules in the IL-1 family appear to promote an inflammatory response, IL-37 modulates or downgrades inflammation.
Charles A. Dinarello, MD, from the University of Colorado, recently expressed human IL-37 in lab mice, which do not have an orthologue, or similar molecule, for this particular cytokine.
The mice were then fed water containing dextran sulfate sodium (DSS), a substance that induces colitis, to see whether IL-37 provided protection from intestinal inflammation.
“While we still don”t understand its mechanism of action, our hope is that, in the future, scientists may be able to engineer cells to overproduce IL-37 and use it to treat or control an overactive immune system in humans,” said lead author Jesus Rivera-Nieves.
That would represent a major advance in treating inflammatory bowel disease (IBD), particularly for the 30 to 50 percent of IBD patients for whom highly effective biological therapies – tumor necrosis factor inhibitors – don”t work, or for an even larger percentage of patients whose symptoms eventually return.
The study will be published this week in Proceedings of the National Academy of Sciences.